S7-1. Mechanism of pallidal deep brain stimulation for dystonia
نویسندگان
چکیده
منابع مشابه
Both thalamic and pallidal deep brain stimulation for myoclonic dystonia.
Myoclonic dystonia is poorly managed with medication and may be severe enough to warrant surgical intervention. Surgery has targeted either the globus pallidus pars interna (GPi) or the thalamus, but there is no accepted target for this condition. The authors present the case of a 23-year-old man treated with unilateral deep brain stimulation in both the thalamus and GPi. His movement disorder ...
متن کاملHypokinesia upon Pallidal Deep Brain Stimulation of Dystonia: Support of a GABAergic Mechanism
In the past, many studies have documented the beneficial effects of deep brain stimulation (DBS) in the globus pallidus internus for treatment of primary segmental or generalized dystonia. Recently however, several reports focused on DBS-induced hypokinesia or freezing of gait (FOG) as a side effect in these patients. Here we report on two patients suffering from FOG after successful treatment ...
متن کاملDeep brain stimulation for dystonia.
The few controlled studies that have been carried out have shown that bilateral internal globus pallidum stimulation is a safe and long-term effective treatment for hyperkinetic disorders. However, most recent published data on deep brain stimulation (DBS) for dystonia, applied to different targets and patients, are still mainly from uncontrolled case reports (especially for secondary dystonia)...
متن کاملDeep brain stimulation of globuspallidusinternus for DYT1 positive primary generalized dystonia
Background : Deep brain stimulation (DBS) of the globuspallidusinternus (GPi) is recommended as a promising technique for the management of the primary generalized dystonia (PGD) with DYT1 gene mutation. We present the first report of DBS results in Iranian patients with DYT1 positive PGD. Methods : Nine patients who suffered from severely disabling DYT1 positive PGD consecutively were recr...
متن کاملNeuroplasticity following pallidal stimulation for dystonia
Dystonia is a disabling condition characterised by involuntary muscle spasms and abnormal postures. Its pathophysiology is incompletely understood but most lines of evidence point to an underlying defect of basal ganglia function leading to abnormal corticomotor output. Various abnormalities have been shown, including abnormal neuronal activity in basal ganglia output nuclei, defective neural i...
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ژورنال
عنوان ژورنال: Clinical Neurophysiology
سال: 2019
ISSN: 1388-2457
DOI: 10.1016/j.clinph.2019.06.097